Selective mGlu2 receptor positive allosteric modulator
TASP 0433864 is a selective mGlu2 receptor positive allosteric modulator (EC50 values are 199 and 206 nM for human and rat receptors, respectively). Exhibits negligible activity against a range of neurotransmitter targets, except 5-HT2B and MAO-B (72 and 92% inhibition at 10 μM, respectively). Potentiates inhibitory effect of DCG IV (Cat. No. 0975) on excitatory postsynaptic potentials in hippocampal slices and ketamine- and methamphetamine-induced increases in locomotor activity in rats and mice.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125714 |
| Réf. fabricant | 18733978 |
| Nom chimique ou matériau | (2S)-2-[[4-(1,1-Dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methylimidazo[2,1-b]oxazole-6-carboxamide |
| CAS | 1431980-60-7 |
| Synonyme | mGlu2 receptor positive allosteric modulator |
| Quantité | 50 mg |
| Solubilité | Soluble to 100mM in DMSO and to 20mM in ethanol |
| Formule moléculaire | C<sub>18</sub>H<sub>23</sub>N<sub>3</sub>O<sub>3</sub> |
| Poids de la formule | 329.39 |
| Forme physique | Solid |
| Couleur | White |
| Type de produit | Bioactive Small Molecule |
| Pureté | >98% |
