"/> Tocris Bioscience™ TAK 779 | B-LABO France

Tocris Bioscience™ TAK 779

Name: Tocris Bioscience™ TAK 779
Brand: Tocris Bioscience
SKU: 18727196
Price: 253.77 EUR
Availability: InStock

Réf. : BL-RE-125735Réf. fabricant : 18727196 10 mg

253,77 € HT

Potent and selective CCR5 and CCR2 chemokine receptor antagonist

Nom chimique ou matériau: N-[[4-[[[6,7-Dihydro-2-(4-methylphenyl)-5 H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-2 H-pyran-4-aminium chloride
CAS: 229005-80-5
Quantité: 10 mg
Cible: Chemokine Receptor Antagonists
Formule moléculaire: C₃₃H₃₉N₂O₂.Cl
Marque: Tocris Bioscience

TAK 779 is a potent and selective CCR5 and CCR2 chemokine receptor antagonist (IC50 values = 1 nM and 27 nM, respectively). TAK 779 blocks the binding of macrophage inflammatory protein 1α and 1β to CHO cells (IC50 = 1 nM) and inhibits replication of R5 HIV-1 at 1.6-3.7 nM. In animal models, TAK 779 protects against ischemic brain injury and prevents development of asthma features.

Caractéristiques techniques

Marque	Tocris Bioscience
Réf. B-LABO	BL-RE-125735
Réf. fabricant	18727196
Nom chimique ou matériau	N-[[4-[[[6,7-Dihydro-2-(4-methylphenyl)-5 H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-2 H-pyran-4-aminium chloride
CAS	229005-80-5
Quantité	10 mg
Cible	Chemokine Receptor Antagonists
Formule moléculaire	C<sub>33</sub>H<sub>39</sub>N<sub>2</sub>O<sub>2</sub>.Cl
Pureté	0.98

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Tocris Bioscience™ TAK 779

Caractéristiques techniques

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