"/> Tocris Bioscience™ AMG 510 | B-LABO France

Tocris Bioscience™ AMG 510

Name: Tocris Bioscience™ AMG 510
Brand: Tocris Bioscience
SKU: 18717466
Price: 208.42 EUR
Availability: InStock

Réf. : BL-RE-125742Réf. fabricant : 18717466 10 mg

208,42 € HT

Potent and selective KRASG12C inhibitor

Nom chimique ou matériau: (1 R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2 S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1 H)-one
CAS: 2252403-56-6
Quantité: 10 mg
Cible: Ras GTPase Inhibitors
Formule moléculaire: C₃₀H₃₀F₂N₆O₃
Marque: Tocris Bioscience

AMG 510 is a potent and selective covalent KRASG12C inhibitor (IC50 = 90 nM). Also a potent inhibitor of phospho-ERK (IC50 = 68 nM). In an

in vivo

model of non-small cell lung cancer, AMG 510 causes regression of tumors, an increase in T-cell recruitment and a pro-inflammatory tumor microenvironment. Synergises with MEK inhibitors and Carboplatin (Cat. No. 2626) and is orally bioavailable.

Caractéristiques techniques

Marque	Tocris Bioscience
Réf. B-LABO	BL-RE-125742
Réf. fabricant	18717466
Nom chimique ou matériau	(1 R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2 S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1 H)-one
CAS	2252403-56-6
Quantité	10 mg
Cible	Ras GTPase Inhibitors
Formule moléculaire	C<sub>30</sub>H<sub>30</sub>F<sub>2</sub>N<sub>6</sub>O<sub>3</sub>
Pureté	0.98

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Tocris Bioscience™ AMG 510

Caractéristiques techniques

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