PKB/Akt inhibitor; also modulates Kv2.1 current
Perifosine is a PKB/Akt inhibitor; accumulates in and reorganizes lipid rafts disrupting Akt signaling. Also inhibits MAPK pathway and induces autophagy. Induces apoptosis in leukemia cell lines. Decreases Kv2.1 current amplitude by modulating its inactivation gating. Antitumor. Orally bioavailable.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125782 |
| Réf. fabricant | 18723168 |
| Nom chimique ou matériau | Perifosine |
| CAS | 157716-52-4 |
| Synonyme | Octadecyl-(1,1-dimethyl-4-piperidylio) phosphate |
| Quantité | 10 mg |
| Solubilité | Soluble to 100mM in water and to 100mM in ethanol |
| Formule moléculaire | C<sub>25</sub>H<sub>52</sub>NO<sub>4</sub>P |
| Poids de la formule | 461.66 |
| Forme physique | Solid |
| Couleur | White |
| Type de produit | Bioactive Small Molecule |
| Pureté | >98% |
