"/> Tocris Bioscience™ FC 11 | B-LABO France

Tocris Bioscience™ FC 11

Réf. : BL-RE-125808Réf. fabricant : 18796636 2 mg
562,62 € HT

Highly potent focal adhesion kinase (FAK) Degrader (PROTAC™)

Nom chimique ou matériau
1-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-1 H-1,2,3-triazole-4-carboxamid
CAS
2271035-37-9
Quantité
2 mg
Cible
FAK
Formule moléculaire
C41H42F3N13O9S
Marque
Tocris Bioscience

FC 11 is a highly potent focal adhesion kinase (FAK) PROTAC™ Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat. No. 6302). The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-125808
Réf. fabricant18796636
Nom chimique ou matériau1-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-1 H-1,2,3-triazole-4-carboxamid
CAS2271035-37-9
Quantité2 mg
CibleFAK
Formule moléculaireC<sub>41</sub>H<sub>42</sub>F<sub>3</sub>N<sub>13</sub>O<sub>9</sub>S
Pureté0.98
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