Wnt/β-catenin signaling inhibitor
KYA 1797K is a Wnt/β-catenin signaling inhibitor (IC50 = 0.75 μM). Increases binding affinity of β-catenin for axin, GSK-3β and β-TrCP. Promotes formation of the destruction complex, activation of GSK-3β and phosphorylation of β-catenin and K-Ras, leading to their degradation via the ubiquitin/proteasome system. Reduces levels of β-catenin and K-Ras and inhibits growth of colorectal cancer (CRC) cells
in vitro
and in mouse xenograft models.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125812 |
| Réf. fabricant | 18084782 |
| Nom chimique ou matériau | (5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt |
| CAS | 1956356-56-1 |
| Quantité | 5 mg |
| Formule moléculaire | C<sub>17</sub>H<sub>11</sub>KN<sub>2</sub>O<sub>6</sub>S<sub>2</sub> |
| Pureté | 98% |
