Potent and highly selective ROCK inhibitor; orally active
TC-S 7001 (also known as BAY-549) is a potent and highly selective ROCK inhibitor (IC50 values are 0.6 and 1.1 nM for human ROCK1 and ROCK2, respectively), which exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. TC-S 7001 reduces blood pressure in normotensive and hypertensive rats, and is orally active.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125843 |
| Réf. fabricant | 18720779 |
| Nom chimique ou matériau | 6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine |
| CAS | 867017-68-3 |
| Synonyme | Azaindole-1 |
| Quantité | 1 mg |
| Cible | Rho-kinase Inhibitors |
| Formule moléculaire | C<sub>18</sub>H<sub>13</sub>ClF<sub>2</sub>N<sub>6</sub>O |
| Poids de la formule | 402.79 |
| Pureté | >98% |
