Positive allosteric modulator of NMDA receptors; acts in transmembrane domain
GNE 9278 is a positive allosteric modulator of NMDA receptors. Potentiates NMDA receptors containing GluN2A, 2B, 2C and 2D subunits (EC50 values are 0.74, 3.07, 0.47 and 0.32 μM in a Ca2+ influx assay, respectively). Binds within the transmembrane domain and displays preference for agonist-bound NMDA receptors. Slows receptor deactivation and enhances the potency of glutamate and glycine .
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125916 |
| Réf. fabricant | 18756306 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>21</sub>H<sub>27</sub>N<sub>5</sub>O<sub>3</sub>S |
| Poids de la formule | 429.54 |
| Type de produit | Positive Allosteric Modulator |
| Pureté | 98% |
