Toll-like receptor 4 (TLR4) signaling inhibitor
TAK 242 is a toll-like receptor 4 (TLR4) signaling inhibitor. Binds to intracellular domain of TLR4. Inhibits LPS-induced cytokine production
in vitro
(IC50 values are 1.3, 1.3 and 3.2 nM for IL-6, TNFα and NO production). Reduces lesion volume in a mouse model of cerebral cavernous malformations (CCMs). Also attenuates increased cytokine levels in a mouse sepsis model, when given in combination with ceftazidime. Cell permeable.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125939 |
| Réf. fabricant | 18717876 |
| Nom chimique ou matériau | (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate |
| CAS | 243984-11-4 |
| Quantité | 5 mg |
| Formule moléculaire | C<sub>15</sub>H<sub>17</sub>ClFNO<sub>4</sub>S |
| Poids de la formule | 361.82 |
| Pureté | 98% |
