Potent group I PAK inhibitor
FRAX 597 is a potent group I PAK inhibitor (IC50 values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). FRAX 597 exhibits significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC50 >10 μM for PAK4). FRAX 597 inhibits proliferation of pancreatic cancer and schwannoma cells
in vitro
and exhibits antitumor effects in mice.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125971 |
| Réf. fabricant | 18788198 |
| Nom chimique ou matériau | FRAX 597 |
| CAS | 1286739-19-2 |
| Synonyme | 6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one |
| Quantité | 50 mg |
| Solubilité | Soluble to 20mM in DMSO |
| Cible | PAK Inhibitors |
| Formule moléculaire | C<sub>29</sub>H<sub>28</sub>ClN<sub>7</sub>OS |
| Poids de la formule | 558.1 |
| Forme physique | Solid |
| Couleur | Yellow |
| Type de produit | Bioactive Small Molecule |
| Pureté | >98% |
