PKR inhibitor
C16 is a PKR inhibitor (IC50 = 210 nM). Rescues PKR-dependent translation block
in vitro
. Decreases Aβ42-induced inflammatory cytokine release and apoptosis in neuronal cultures. Prevents neuroinflammation and neuronal loss in an acute excitotoxic rat model. Brain penetrant.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125995 |
| Réf. fabricant | 18784049 |
| Nom chimique ou matériau | C16 |
| CAS | 608512-97-6 |
| Synonyme | 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one |
| Quantité | 10 mg |
| Solubilité | Soluble to 50mM in DMSO and to 20mM in ethanol |
| Formule moléculaire | C<sub>1</sub><sub>3</sub>H<sub>8</sub>N<sub>4</sub>OS |
| Poids de la formule | 268.29 |
| Forme physique | Solid |
| Type de produit | Bioactive Small Molecule |
| Pureté | >98% |
