S6K1 inhibitor
PF 4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) (Ki = 20 nM; IC50 = 160 nM). Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1; displays no effect on the activity of RSK and MSK
in vivo
. Exhibits no significant inhibition of S6K2 or other AGC kinases (e.g. Akt, PKA and ROCK)
in vitro
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-126002 |
| Réf. fabricant | 18795986 |
| Nom chimique ou matériau | 2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole |
| CAS | 1255517-76-0 |
| Plage de pourcentage du dosage | >98% |
| Quantité | 25 mg |
| Formule moléculaire | C<sub>19</sub>H<sub>21</sub>F<sub>3</sub>N<sub>6</sub> |
| Poids de la formule | Observed MW: 390.41 |
