Potent negative modulator of KCa2.3 and KCa3.1 channels
RA 2 is a potent negative modulator of calcium-activated potassium channels KCa2.3 and KCa3.1 (IC50 values are 2 and 17 nM, respectively), which displays >55-fold selectively for KCa2 and KCa3.1 over other KCa, Kv and Kir channels. In
ex vivo
porcine coronary endothelium, RA 2 inhibits SKA 31 (Cat. No. 3670)-induced KCa2/KCa3.1 currents and TRAM 34 (Cat. No. 2946)-insensitive KCa2 currents. Reduces heart rate in mice in a KCa3.1-dependent manner.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-126005 |
| Réf. fabricant | 18797326 |
| Nom chimique ou matériau | 1,3-Phenylenebis(methylene)bis(3-fluoro-4-hydroxybenzoate) |
| CAS | 1867107-62-7 |
| Quantité | 10 mg |
| Cible | Ca2+-Activated Potassium Channel Modulators |
| Formule moléculaire | C<sub>22</sub>H<sub>16</sub>F<sub>2</sub>O<sub>6</sub> |
| Pureté | 0.98 |
