Selective neutral sphingomyelin phosphodiesterase (N-SMase) inhibitor
GW 4869 is a selective neutral sphingomyelin phosphodiesterase (N-SMase) inhibitor (IC50 = 1 μM). Exhibits selectivity for neutral sphingomyelinase over acid sphingomyelinase (a-SMase) at concentrations up to 150 μM as well as
B. cereus
PC-PLC, human lyso-PAF PLC, and bovine PP2A at 10 μM. Blocks exosome biogenesis. Inhibits TNF-α-induced sphingomyelin hydrolysis and TNF-α-induced cell death in MCF-7 cells. Reverses hypoxia-induced pulmonary vasoconstriction in rats. Neuroprotective.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-126014 |
| Réf. fabricant | 18796266 |
| Nom chimique ou matériau | 3,3 '-(1,4-Phenylene)bis[N-[4-(4,5-dihydro-1 H-imidazol-2-yl)phenyl]-2-propenamide] ditrifluoroacetate |
| Quantité | 10 mg |
| Cible | Hydrolase Inhibitors |
| Formule moléculaire | C<sub>30</sub>H<sub>28</sub>N<sub>6</sub>O<sub>2</sub>0.2 CF<sub>3</sub>COOH |
| Pureté | 0.9 |
