Modulator of alternative polyadenylation; inhibits rod photoreceptor gene expression via Nr2e3
T4 is a modulator of alternative polyadenylation (APA) (IC50 values are 2.1 μM and 8.5 μM in U2OS and 293T cells, respectively). T4 promotes distal-to-proximal APA usage in multiple transcripts, using distinctive A-rich motifs through autoregulated PABPN1 signaling. T4 exhibits no inhibitory activity against a panel of 414 kinases. T4 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa. T4 inhibits rod photoreceptor gene expression via Nr2e3 in a luciferase-based assay (IC50 = 0.07 μM).
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-126068 |
| Réf. fabricant | 18757586 |
| Nom chimique ou matériau | 6,7-Dimethoxy-2-[((4-phenyl-3,6-dihydropyridin-1(2 H)-yl)methyl)]quinazolin-4(3 H)-one |
| CAS | 785708-33-0 |
| Quantité | 50 mg |
| Cible | DNA, RNA and Protein Synthesis Compounds |
| Formule moléculaire | C<sub>22</sub>H<sub>23</sub>N<sub>3</sub>O<sub>3</sub> |
| Pureté | 0.98 |
