Azide-containing monosaccharide building block; used as glycoprotein, glycolipid and glycoRNA probe
Ac4ManNAz is a cell-permeable, unnatural azide-containing monosaccharide building block. Ac4ManNAz is metabolized and incorporated as azidosialic acid into cell surface and secreted sialoglycoproteins to allow Cu(I)-free click chemistry for further conjugation or detection. Ac4ManNAz can be used for bioorthogonal labeling of human prostate tissue slice cultures; the target sialoglycoproteins can be biotinylated for proteomic analysis or reacted with a cyclooctyne-functionalized optical probe for imaging. Ac4ManNAz is also used to label glycoRNAs on the cell surface.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-126085 |
| Réf. fabricant | 18749016 |
| Nom chimique ou matériau | 2-[(2-Azidoacetyl)amino]-2-deoxy-D-mannopyranose-1,3,4,6-tetraacetate |
| CAS | 361154-30-5 |
| Quantité | 10 mg |
| Cible | Photoactivatable Cross-linking Probes |
| Formule moléculaire | C<sub>16</sub>H<sub>22</sub>N<sub>4</sub>O<sub>10</sub> |
| Pureté | 0.95 |
