Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogeneisis
Chroman 1 is a highly potent and selective ROCK2 (Rho-kinase) inhibitor (IC50 values are 1 and 52 pM at ROCK2 and ROCK1, respectively). Chroman 1 exhibits >2000-fold selectivity for ROCK2 over a range of related kinases including MRCK, PKA, and AKT1 (IC50 values are 150, >20000, and >20000 nM, respectively). Chroman 1 promotes survival of pluripotent stem cells (PSCs) in culture when used in combination with Emricasan (Cat. No. 7310), Polyamines, and Trans-ISRIB (Cat. No. 5284), a combination known as CEPT. When used as part of the CEPT cocktail, Chroman 1 also improves survival of differentiated cells following cryopreservation with cardiomyocyte cell survival increasing by 36% and motor neuron survival improving by 63% compared with DMSO controls.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-126097 |
| Réf. fabricant | 18725466 |
| Nom chimique ou matériau | (3 S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1 H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2 H-1-benzopyran-3-carboxamide dihydrochloride |
| Quantité | 50 mg |
| Cible | Rho-kinase Inhibitors |
| Formule moléculaire | C<sub>24</sub>H<sub>28</sub>N<sub>4</sub>O<sub>4</sub>0.2 HCl |
| Poids de la formule | 12373 |
| Pureté | 98% |
