Tubastatin A hydrochloride is a potent HDAC6 inhibitor (IC50 = 0.015 μM). Exhibits some selectively for HDAC6 over HDAC8 and 1 (IC50 values are 0.854 and 16.4 μM, respectively). Induces elevated levels of α-tubulin and protects against glutathione-induced oxidative stress in primary neuronal cell culture. Reverses the axonal loss in peripheral neurons in a mouse model of Charcot-Marie-Tooth disease.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-126115 |
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| Réf. fabricant | 18727978 |
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| Nom chimique ou matériau | N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride |
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| CAS | 1310693-92-5 |
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| Plage de pourcentage du dosage | >98% |
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| Quantité | 10 mg |
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| Formule moléculaire | C<sub>20</sub>H<sub>21</sub>N<sub>3</sub>O<sub>2</sub>.HCl |
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| Poids de la formule | Observed MW: 371.86 |
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