"/> Tocris™ AP 1903 | B-LABO France

Tocris™ AP 1903

Réf. : BL-RE-126249Réf. fabricant : 18727356 5 mg
440,59 € HT

Chemical inducer of protein dimerization; active in vivo

Nom chimique ou matériau
2,2 '-[1,2-Ethanediylbis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1 R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[(2 S)-1-[(2 S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate]
CAS
195514-63-7
Quantité
5 mg
Cible
Protein Dimerizers
Formule moléculaire
C78H98N4O20
Marque
Tocris

AP 1903 is a chemical protein dimerizer for use in FKBP fusion protein systems. Induces apoptosis in cells expressing a fusion protein consisting of FKBPF36V and intracellular domain of Fas receptor with high potency (EC50 = 0.1 nM). Exhibits >50-fold selectivity for FKBPF36V-Fas fusion protein over wild-type FKBP. Also induces apoptosis in cells expressing Cas9-FK506 fusion proteins, in inducible caspase 9 (iCas9) suicide gene system. Active

.

Caractéristiques techniques

MarqueTocris
Réf. B-LABOBL-RE-126249
Réf. fabricant18727356
Nom chimique ou matériau2,2 '-[1,2-Ethanediylbis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1 R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[(2 S)-1-[(2 S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate]
CAS195514-63-7
Quantité5 mg
CibleProtein Dimerizers
Formule moléculaireC<sub>78</sub>H<sub>98</sub>N<sub>4</sub>O<sub>20</sub>
Pureté0.98
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