Potent TGF-βRI inhibitor
AZ 12799734 is a potent inhibitor of transforming growth factor-β type I receptor (TGF-βRI; ALK5) (IC50 = 17 nM in cellular inhibition assay and 47 nM in TGF-β-induced luciferase activity assay). Also inhibits ALK4, ALK6 and ALK7 at concentrations under 10 μM. Inhibits BMP signaling, phosphorylation of SMAD1 and SMAD2, and TGF-β-induced epithelial cell migration
in vitro
. Displays cardiotoxicity
in vivo
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-126255 |
| Réf. fabricant | 18735836 |
| Nom chimique ou matériau | 4-[[4-[(2.6-Dimethyl-3-pyridinyl)oxy]-2-pyridinyl]amino]benzenesulfonamide |
| CAS | 1117684-36-2 |
| Quantité | 10 mg |
| Formule moléculaire | C<sub>18</sub>H<sub>18</sub>N<sub>4</sub>O<sub>3</sub>S |
| Pureté | 98% |
