Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry
tri-GalNAc-PEG3-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; each molecule incorporates three ASGPR ligands with a PEG3 linker and azide group reactive handle ready for conjugation. Upon binding to the ASGPR, tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-126300 |
| Réf. fabricant | 18786275 |
| CAS | 2925590-71-0 |
| Quantité | 1 mg |
| Cible | Degrader Building Blocks |
| Formule moléculaire | C<sub>70</sub>H<sub>125</sub>N<sub>13</sub>O<sub>31</sub> |
| Pureté | 0.9 |
