Highly selective σ1 agonist
Pridopidine is a selective high affinity σ-1 receptor (S1R) agonist (Ki = 7.1 nM in both HEK293 cells and rat striatal membranes). Pridopidine displays ∼30-fold and ∼100-fold selectivity over the dopamine D3 receptor and the D2 receptor, respectively. Pridopidine is a low affinity dopamine D2 receptor antagonist (Ki (low) = 17.5 μM; Ki (high) = 7.5 μM). Pridopidine upregulates gene expression induced by BDNF in rat striatum
in vivo
in an S1R-dependent manner. Pridopidine improves motor function and shows neuroprotective effects in Huntington's disease animal models. Pridopidine restores neuromuscular junction activity in amyotrophic lateral sclerosis models
in vitro
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-126310 |
| Réf. fabricant | 18706056 |
| Nom chimique ou matériau | 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine |
| CAS | 346688-38-8 |
| Quantité | 50 mg |
| Cible | Sigma1 Receptor Agonists |
| Formule moléculaire | C<sub>15</sub>H<sub>23</sub>NO<sub>2</sub>S |
| Pureté | 98% |
