Promotes mitochondrial Rho GTPase 1 (Miro1) degradation
Miro1 Reducer is a promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-126319 |
| Réf. fabricant | 18798426 |
| Nom chimique ou matériau | N-(3-Fluorophenyl)-N'-[4-[[6-(1 H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]urea hydrochloride |
| Quantité | 10 mg |
| Cible | Rhot1 |
| Formule moléculaire | C<sub>20</sub>H<sub>16</sub>FN<sub>7</sub>O.HCl |
| Pureté | 0.98 |
