"/> Tocris™ LY 2886721 Hydrochloride | B-LABO France

Tocris™ LY 2886721 Hydrochloride

Réf. : BL-RE-126325Réf. fabricant : 18748326 50 mg
1 153,32 € HT

Potent and selective β-secretase (BACE) inhibitor

Nom chimique ou matériau
N-[3-[(4 AS,7 AS)-2-Amino-4 A,5-dihydro-4 H-furo[3,4-d][1,3 ]thiazin-7 A(7 H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride
CAS
1262036-49-6
Quantité
50 mg
Cible
Additional Synthetic Protease Inhibitors
Formule moléculaire
C18H16F2N4O2S.HCl
Marque
Tocris

LY 2886721 Hydrochloride is a potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model.

Caractéristiques techniques

MarqueTocris
Réf. B-LABOBL-RE-126325
Réf. fabricant18748326
Nom chimique ou matériauN-[3-[(4 AS,7 AS)-2-Amino-4 A,5-dihydro-4 H-furo[3,4-d][1,3 ]thiazin-7 A(7 H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride
CAS1262036-49-6
Quantité50 mg
CibleAdditional Synthetic Protease Inhibitors
Formule moléculaireC<sub>18</sub>H<sub>16</sub>F<sub>2</sub>N<sub>4</sub>O<sub>2</sub>S.HCl
Pureté0.98
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