Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
ABT 737 is a high affinity Bcl-2 family inhibitor (Ki ≤ 1nM for Bcl-XL, Bcl-2 and Bcl-w). BH3 mimetic; triggers Bax/Bak-mediated apoptosis. Exhibits cytotoxicity in lymphoma cell lines overexpressing
bcl-2
(EC50 < 1 μM) and multiple myeloma cells (IC50 = 5-15 μM). Induces apoptosis in patient-derived CLL cells. Promotes regression of SCLC tumors in a mouse xenograft model. Synergizes with certain other anticancer agents.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-126328 |
| Réf. fabricant | 18738876 |
| Quantité | 10 mg |
| Formule moléculaire | <sub>C42</sub>H<sub>45</sub>ClN<sub>6</sub>O<sub>5</sub>S<sub>2</sub> |
| Poids de la formule | 813.43 |
| Type de produit | Inhibitor |
| Pureté | 98% |
