ISCK03 (inhibitor of SCF/c-KIT) is a cell-permeable phenyl-imidazolosulfonamide compound that inhibits KIT activity
ISCK03 inhibits SCF-induced c-KIT phosphorylation and downstream ERK phosphorylation at a concentration of 1 - 5 μM in 501mel melanoma cells (Na et al.)
Causes significant decrease in blood vessel density on human lung adenocarcinoma (A549) cells irradiated with X-rays (6 Gy; Kamlah et al.)
Reduces cell viability and ERK1/2 phosphorylation in acute myeloid leukemia (AML)-derived cell lines (Kon et al.)
