ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC)
673 A is an aldehyde dehydrogenase (ALDH1A) inhibitor (IC50 values are 230, 246 and 348 nM for ALDH1A2, ALDH1A1 and ALDH1A3, respectively). Exhibits >40-fold selectivity for ALD1A over ALDH2. Depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. Triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP). Overcomes chemotherapy resistance
in vivo
.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-126767 |
| Réf. fabricant | 18717596 |
| Quantité | 10 mg |
| Formule moléculaire | C<sub>15</sub>H<sub>13</sub>NO |
| Poids de la formule | 223.28 |
| Type de produit | Inhibitor |
| Pureté | 98% |
