Allosteric AMPK activator
ZLN 024 hydrochloride is an allosteric AMP-activated protein kinase (AMPK) activator; allosterically stimulates active AMPK heterotrimers, increasing the activity of α1β1γ1 by 1.5-fold and α2β1γ1 by 1.7-fold (EC50 values are 0.42 and 0.95 μM, respectively). Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα. Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. Also decreases fatty acid synthesis and glucose output in primary hepatocytes. Improves glucose tolerance and decreases cholesterol content in
db/db
mice.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-126804 |
| Réf. fabricant | 18776209 |
| Nom chimique ou matériau | 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride |
| Quantité | 50 mg |
| Cible | AMPK Activators |
| Formule moléculaire | C1<sub>3</sub>H<sub>13</sub>BrN<sub>2</sub>OS.HCl |
| Poids de la formule | 361.69 |
| Pureté | >99% |
