Positive allosteric modulator of M1 receptors
BQCA is a muscarinic M1 receptor positive allosteric modulator (pKB 5.76 - 5.82). Exhibits selectivity for M1 over M3 and M5 receptors. Enhances ACh effects at M1 receptors in an IP1- accumulation assay, without affecting ACh binding. Increases markers of neuronal activation in brains of wild-type but not M1-/- mice
in vivo
. Prevents Scopolamine (Cat. No. 1414)-induced memory deficits in mice in a contextual fear conditioning model.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-126811 |
| Réf. fabricant | 18777806 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>18</sub>H<sub>15</sub>NO<sub>4</sub> |
| Poids de la formule | 309.32 |
| Type de produit | Positive Allosteric Modulator |
| Pureté | 98% |
