STAT3 inhibitor; active in vivo
Galiellalactone is a STAT3 inhibitor. Irreversibly binds STAT3 and inhibits binding to DNA. Inhibits IL-6-dependent JAK/STAT signaling. Induces cell-cycle arrest in G2/M phase and apoptosis in androgen-insensitive prostate cancer cells via activation of ATM/ATR pathway. Also destabilizes microtubules and inhibits cell migration. Exhibits anticancer effects in a mouse tumor xenograft model.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-128387 |
| Réf. fabricant | 18751368 |
| Type de produit | Inhibitor |
| Protéines cibles | STAT |
| CAS | 133613-71-5 |
| Formule moléculaire | C<sub>11</sub>H<sub>14</sub>O<sub>3</sub> |
| Poids de la formule | 194.23g/mol |
| Contenu et stockage | Store at -20°C |
| À utiliser avec (application) | STAT Inhibitors |
| Quantité | 500 μg |
