High-affinity inhibitor of VHL
VH 298 is a high-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes, with similar transcriptional profile to hypoxia. Cell permeable.
Negative control cis VH 298 also available.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-128434 |
| Réf. fabricant | 18770268 |
| Type de produit | Inhibitor |
| Protéines cibles | Ubiquitin Ligase (E3) |
| Formule moléculaire | C<sub>27</sub>H<sub>33</sub>N<sub>5</sub>O<sub>4</sub>S |
| Poids de la formule | 523.65g/mol |
| Contenu et stockage | Store at -20°C |
| À utiliser avec (application) | Ubiquitin Ligase (E3) Inhibitors |
| Quantité | 50 mg |
