Selective non-ATP competitive inhibitor of GSK 3β
TDZD 8 is a selective non-ATP competitive inhibitor of GSK 3β (IC50 = 2 μM); thiadiazolidinone deriviative. Does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. Reduces severity of L-dopa-induced dyskinesia in a Parkinson's disease
in vivo
model.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-128438 |
| Réf. fabricant | 18719508 |
| Couleur | White |
| Type de produit | Inhibitor |
| CAS | 327036-89-5 |
| Formule moléculaire | C<sub>10</sub>H<sub>10</sub>N<sub>2</sub>O<sub>2</sub>S |
| Poids de la formule | 222.26g/mol |
| Synonyme | NP 01139 |
| Solubilité | Soluble to 100mM in DMSO, 100mM in ethanol |
| Contenu et stockage | Store at -20°C |
| À utiliser avec (application) | Inhibits GSK 3β |
| Quantité | 10 mg |
