This shuttle vector contains the complete ORF for the gene of interest, along with a Kozak consensus sequence for optimal translation initiation. It is inserted NotI to AscI. The gene insert is flanked with convenient multiple cloning sites which can be used to easily cut and transfer the gene cassette into your desired expression vector.
Expression
mAntxr1sity
Numéro d’adhésion
NP_473382
Concentration
10 μg at 0.2 μg/μL
Formule
cDNA is provided in 10 mM Tris-Cl, pH 8.5
Type d’insert
1702 bp
Marque
R&D Systems
Caractéristiques principales
Also known as: Tem8; Antrx1; 2310008J16Rik; 2810405N18Rik
ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer.
It has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax.
The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to ANTXR1 mediates delivery of toxin components to the cytosol of cells.
Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.
The TEM8/ANTXR1 insert is sequence verified and the entire plasmid DNA and insert translated sequences are provided.
For reasearch use only. Not for use in humans.
Caractéristiques techniques
Marque
R&D Systems
Réf. B-LABO
BL-RE-144567
Réf. fabricant
18767648
Expression
<i>m</i>Antxr1sity
Numéro d’adhésion
NP_473382
Concentration
10 μg at 0.2 μg/μL
Formule
cDNA is provided in 10 mM Tris-Cl, pH 8.5
Type d’insert
1702 bp
Identification génétique (Entrez)
84168
Contenu et stockage
Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Espèces
Mouse
Quantité
10 μg
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