Potent and selective TRPV1 antagonist
AMG 21629 is a potent and selective TRPV1 antagonist. Blocks Ca2+ uptake by CHO cells expressing TRPV1 receptors (IC50 values are 0.6 and 0.8 nM for capsaicin (Cat. No. 0462) and acid-induced Ca2+ uptake, respectively). Exhibits >4000-fold selectivity for TRPV1 over other TRP channels. Blocks capsaicin-induced flinch response and causes hyperthermia in rats. Orally available and non-CNS penetrant.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-151115 |
| Réf. fabricant | 18760769 |
| Nom chimique ou matériau | 3-Amino-5-[[2-[(2-methoxyethyl)amino]-6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2(1H)-quinoxalinone |
| CAS | 939040-79-6 |
| Quantité | 1 mg |
| Cible | TRPV Antagonists |
| Formule moléculaire | C<sub>22</sub>H<sub>19</sub>F<sub>3</sub>N<sub>6</sub>O<sub>3</sub> |
| Poids de la formule | 472.42 |
| Pureté | >97% |
