BMX-IN-1 is a potent and irreversible BMX inhibitor (IC50 = 25 nM). Covalently modifies Cysteine 496. Demonstrates selectivity over other Tec family members with identically positioned reactive cysteine residue
in vitro
. Reduces cell number and induces apoptosis in prostate cancer cell lines. Also inhibits proliferation and reduces viability in HeLa and SiHa cell lines.
Caractéristiques techniques
| Marque | Tocris |
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| Réf. B-LABO | BL-RE-151232 |
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| Réf. fabricant | 18701849 |
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| Nom chimique ou matériau | N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide |
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| CAS | 1431525-23-3 |
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| Plage de pourcentage du dosage | >98% |
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| Quantité | 5 mg |
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| Formule moléculaire | C<sub>29</sub>H<sub>24</sub>N<sub>4</sub>O<sub>4</sub>S |
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| Poids de la formule | Observed MW: 524.59 |
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