AT 1 is a cell penetrant Proteolysis Targeting Chimera (PROTAC®) compound based on (+)-JQ1 (Cat.No. 4499) conjugated to a von Hippel-Lindau (VHL) ligand. Rationally designed based on a ternary complex crystal structure to improve selectivity for BRD4 degradation compared to MZ1 (Cat.No. 6154). Demonstrates profound and selective degradation of BRD4 in cells at 1-3 μM, with negligible loss of BRD2 and BRD3.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license
Caractéristiques techniques
| Marque | Tocris |
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| Réf. B-LABO | BL-RE-151257 |
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| Réf. fabricant | 18738796 |
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| Nom chimique ou matériau | (2S,4R)-1-(2R)-2-Acetamido-3-[[6-[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamido]hexyl]thio]-3-methylbutanoyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl)pyrrolidinine-2-carboxamide |
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| CAS | 2098836-45-2 |
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| Plage de pourcentage du dosage | >98% |
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| Quantité | 5 mg |
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| Formule moléculaire | C<sub>48</sub>H<sub>58</sub>ClN<sub>9</sub>O<sub>5</sub>S<sub>3</sub> |
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| Poids de la formule | Observed MW: 972.68 |
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