Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant
VU 0650991 is a noncompetitive glucagon-like peptide-1 (GLP-1) receptor antagonist (IC50 = 0.65 - 0.69 μM). Displays >40-fold selectivity for GLP-1 receptor over glucagon receptors. Blocks activity of Exendin-4 (Cat. No. 1933) in potentiating insulin secretion from primary mouse pancreatic islets
in vitro
. Decreases blood insulin and increases blood glucose levels
in vivo
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-151338 |
| Réf. fabricant | 18736046 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>16</sub>H<sub>11</sub>ClF<sub>6</sub>N<sub>4</sub>O<sub>2</sub> |
| Poids de la formule | 440.73 |
| Type de produit | Antagonist |
| Pureté | 98% |
