Potent and selective BRD1 and TAF1 inhibitor
BAY 299 is a potent and selective BRD1 and TAF1 inhibitor (IC50 values are 6-67 and 8-13 nM, respectively). Displays selectivity over other bromodomains (>30-fold over other members of the BRPF family; BRD9 and ATAD2; >300-fold over BRD4). Displays BRD1 and TAF1 inhibition in a NanoBRET cell assay. Inhibits binding of BRD1 and TAF1 to histone H4 (IC50 values are 575 nM and 0.9 μM, respectively) and histone H3.3 (IC50 values are 825 nM and 1.4 μM, respectively).
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-151350 |
| Réf. fabricant | 18704039 |
| Nom chimique ou matériau | 6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione |
| CAS | 2080306-23-4 |
| Plage de pourcentage du dosage | >98% |
| Quantité | 25 mg |
| Formule moléculaire | C<sub>25</sub>H<sub>23</sub>N<sub>3</sub>O<sub>4</sub> |
| Poids de la formule | Observed MW: 429.47 |
