Potent TAOK inhibitor
CP 43 is a potent TAO kinase (TAOK) inhibitor (IC50 values are 11 nM/L and 15 nM/L for TAOK1 and TAOK2, respectively). Inhibits TAOK phosphorylation and activation of JNK
in vitro
. Prolongs duration of mitosis and increases mitotic cell death in the SKBR3 breast cancer cell line. Also reduces tau phopshorylation in cortical neurons at sites associated with neurodegeneration in human tauopathies.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-151380 |
| Réf. fabricant | 18722188 |
| Nom chimique ou matériau | N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1′-biphenyl]-4-carboxamide |
| CAS | 850467-66-2 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>25</sub>H<sub>24</sub>N<sub>2</sub>O<sub>2</sub> |
| Pureté | 98% |
