ASIC blocker; active in vivo
NS 383 is an ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-151393 |
| Réf. fabricant | 18758636 |
| Nom chimique ou matériau | 8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1 H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime |
| CAS | 309711-59-9 |
| Quantité | 10 mg |
| Cible | Acid-sensing Ion Channel Blockers |
| Formule moléculaire | C<sub>19</sub>H<sub>19</sub>N<sub>3</sub>O<sub>2</sub> |
