"/> Tocris Bioscience™ Ozanimod | B-LABO France

Tocris Bioscience™ Ozanimod

Réf. : BL-RE-151407Réf. fabricant : 18768636 50 mg
673,85 € HT

Potent and selective S1P1 and S1P5 agonist

Nom chimique ou matériau
5-[3-[(1 S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1 H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile
CAS
1306760-87-1
Quantité
50 mg
Cible
Sphingosine-1-phosphate Receptor Agonists
Formule moléculaire
C23H24N4O3
Marque
Tocris Bioscience

Ozanimod is a potent and selective sphingosine-1-phosphate receptor 1 (S1P1) and 5 (S1P5) agonist (EC50 values are 0.41 and 11 nM, respectively, in a [35S]-GTPγS assay). Ozanimod exhibits 27-fold selectivity over S1P5, and >10,000-fold selectivity over S1P2-4.

In vitro

, Ozanimod induces sustained S1P1 receptor internalization and degradation in S1P1 receptor-HEK293T cells.

In vivo

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-151407
Réf. fabricant18768636
Nom chimique ou matériau5-[3-[(1 S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1 H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile
CAS1306760-87-1
Quantité50 mg
CibleSphingosine-1-phosphate Receptor Agonists
Formule moléculaireC<sub>23</sub>H<sub>24</sub>N<sub>4</sub>O<sub>3</sub>
Pureté0.98
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