"/> Tocris™ SJFa SJFalpha SJFalpha | B-LABO France

Tocris™ SJFa SJFalpha SJFalpha

Réf. : BL-RE-151483Réf. fabricant : 18758416 5 mg
313,17 € HT

Potent and selective p38α PROTAC™

Nom chimique ou matériau
N-(3-Fluoro-4-((7-(4-(4-(2-((-1-((2 S,4 R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)butoxy)butoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarb
CAS
2254609-27-1
Quantité
5 mg
Cible
Active Degraders
Formule moléculaire
C59H67F2N7O11S
Marque
Tocris

SJFα is a potent and selective p38α PROTAC™ Degrader (DC50 = 7.16 nM and Dmax = 97.4%). SJFα comprises the multikinase inhibitor foretinib joined by a linker to a VHL ligand. Displays significantly lower potency degradation at p38δ (DC50 = 299 nM). Exhibits no significant degradation of p38β or γ. or related MAPKs, ERK1/2, or JNK1/2.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license

.

Caractéristiques techniques

MarqueTocris
Réf. B-LABOBL-RE-151483
Réf. fabricant18758416
Nom chimique ou matériauN-(3-Fluoro-4-((7-(4-(4-(2-((-1-((2 S,4 R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)butoxy)butoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarb
CAS2254609-27-1
Quantité5 mg
CibleActive Degraders
Formule moléculaireC<sub>59</sub>H<sub>67</sub>F<sub>2</sub>N<sub>7</sub>O<sub>11</sub>S
Pureté0.98
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