Potent and metabolically stable RIP1 kinase inhibitor
RIPA 56 is a potent and metabolically stable receptor-interacting protein kinase 1 (RIPK1) inhibitor (EC50 = 13 nM). RIPA-56 shows no inhibition of RIP3 kinase at 10 μM . RIPA 56 blocks necroptosis and aging of the mouse male reproductive system. RIPA 56 reduces tumor necrosis factor α (TNFα)-induced mortality and multi-organ damage in a mouse model of systemic inflammatory response syndrome (SIRS). RIPA 56 is orally bioavailable.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-151504 |
| Réf. fabricant | 18746666 |
| Nom chimique ou matériau | N-Hydroxy-2,2-dimethyl-N-(phenylmethyl)butanamide |
| CAS | 1956370-21-0 |
| Quantité | 50 mg |
| Cible | RIP Kinase Inhibitors |
| Formule moléculaire | C<sub>13</sub>H<sub>19</sub>NO<sub>2</sub> |
| Pureté | 0.98 |
