Mitochondrial complex I inhibitor
BAY 87-2243 is a mitochondrial complex I inhibitor. Exhibits no effect on mitochondrial complex III. Induces mitochondrial permeability transition pore (mPTP) opening, stimulates autophagosome formation and mitophagy, and increases ROS levels. Activates necroptotic and ferroptotic cell death. Also inhibits hypoxia-induced gene activation. Induces cell death in melanoma cell lines
in vitro
and exhibits antitumor activity in a mouse NSCLC xenograft model
in vivo
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-151582 |
| Réf. fabricant | 18788036 |
| Nom chimique ou matériau | 1-Cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]piperazine |
| CAS | 1227158-85-1 |
| Quantité | 25 mg |
| Formule moléculaire | C<sub>26</sub>H<sub>26</sub>F<sub>3</sub>N<sub>7</sub>O<sub>2</sub> |
| Pureté | 98% |
