High affinity XIAP antagonist
A 410099.1 is a high affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines
in vitro
(EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-151595 |
| Réf. fabricant | 18745486 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>27</sub>H<sub>40</sub>N<sub>4</sub>O<sub>3</sub>.HCl |
| Poids de la formule | 505.09 |
| Type de produit | Antagonist |
| Pureté | 98% |
