Potent and selective RIP3 kinase inhibitor
GSK'872 is a potent and selective receptor activating protein kinase 3 (RIP3) inhibitor (IC50 = 1.3 nM). Exhibits >1000-fold selectivity for RIP3 over a panel of 300 other kinases including RIP1. Inhibits TNF-induced cell death in 3T3-SA cells and TLR3-induced necrosis in fibroblasts
in vitro
. Blocks necroptosis of primary human neutrophils from whole blood. Also induces apoptosis at higher concentrations (3 - 10 μM).
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-151607 |
| Réf. fabricant | 18769756 |
| Nom chimique ou matériau | N-5-Benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine |
| CAS | 1346546-69-7 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>19</sub>H<sub>17</sub>N<sub>3</sub>O<sub>2</sub>S<sub>2</sub> |
| Poids de la formule | 383.49 |
| Pureté | 98% |
