Potent FBPase inhibitor; promotes HSC expansion
MB 05032 is a potent FBPase inhibitor (EC50 values are 1.6, 29 and 61 nM for human liver FBPase, human muscle FBPase and rat liver FBPase). Promotes hematopoietic stem cell and progenitor cell expansion. Increases engraftment in primary NSG mice recipients. Also enhances myeloid and lymphoid chimerism in secondary NSG mouse recipients. Promotes glycolysis, glucose uptake and lactate production in umbilical cord blood CD34+ cells.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-151616 |
| Réf. fabricant | 18776796 |
| Nom chimique ou matériau | P-[5-[2-Amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]phosphonic acid |
| CAS | 261365-11-1 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>11</sub>H<sub>15</sub>N<sub>2</sub>O<sub>4</sub>PS |
| Poids de la formule | 302.29 |
| Pureté | 98% |
