HDAC4 CHDI Degrader 11 is a potent and selective HDAC4 Degrader (PROTAC™) (DC50 values are 4 and 6 nM in Jurkat E6-1 and Jurkat cells respectively). Comprises the class IIa HDAC inhibitor trifluoromethyloxadiazole joined by a linker to a ligand for Von Hippel-Lindau (VHL) protein. In a mouse cell model of Huntingtons disease, HDAC4 CHDI Degrader 11 potently degrades HDAC4 (DC50 = 1nM). Can be used with P-glycoprotein inhibitor Elacridar (Cat. No. 4646) for more effective degradation in neuroblastoma cell lines. HDAC4 antibody validated for Simple Western™ (automated Western) instruments also available: Catalog # NBP2-22151 .
PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license
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Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-151622 |
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| Réf. fabricant | 18044052 |
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| Nom chimique ou matériau | (2S,4R)-1-((3R,26S)-26-(tert-Butyl)-3-methyl-1,24-dioxo-5-propyl-1-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)-10,13,16,19,22-pentaoxa-2,5,25-triazaheptacosan-27-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
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| Quantité | 5 mg |
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| Cible | Active Degraders |
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| Formule moléculaire | C<sub>52</sub>H<sub>73</sub>F<sub>3</sub>N<sub>8</sub>O<sub>11</sub>S |
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| Pureté | 98% |
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