Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTAC™s
Thalidomide, propargyl is a click-activated Thalidomide (Cat.No. 0652); can be used as a precursor to a PROTAC® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with an alkyne functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
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| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-151670 |
| Réf. fabricant | 18797256 |
| Nom chimique ou matériau | 2-(2,6-Dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)-1<i>H</i>-isoindole-1,3(2<i>H</i>)-dione |
| CAS | 2098487-39-7 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>16</sub>H<sub>12</sub>N<sub>2</sub>O<sub>5</sub> |
| Poids de la formule | 312.28 |
| Type de produit | Alkyne-functionalized Ligand |
| Pureté | 95% |
