AS 1517499 is a potent STAT6 inhibitor (IC50 = 21 nM).
In vitro
, it inhibits IL-4-induced Th2 differentiation of mouse spleen T cells (IC50 = 2.3 nM), without influencing Th1 differentiation induced by IL-12. In a mouse model of allergic bronchial asthma, treatment with AS 1517499 reduces mouse airway IL-3 production and partly inhibits the RhoA upregulation in bronchial smooth muscles.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-151685 |
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| Réf. fabricant | 18755886 |
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| Nom chimique ou matériau | 2-[[2-(3-Chloro-4-hydroxyphenyl)ethyl]amino]-4-[(phenylmethyl)amino]-5-pyrimidinecarboxamide |
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| CAS | 919486-40-1 |
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| Quantité | 10 mg |
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| Cible | STAT6 |
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| Formule moléculaire | C<sub>20</sub>H<sub>20</sub>ClN<sub>5</sub>O<sub>2</sub> |
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| Pureté | 0.98 |
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